The picture below represents the current home screen layout as I currently use it.

TuneIn Radio is great, as is Wikihood.  They both offer something unique or outstanding IMHO.

From left to right starting at the top.

• Google Maps
• Photos
• Earthquakes (notification and visualization of recent earthquakes globally)
• Contacts
• Flickr (Actually this is an iPhone app that you have to run 2x to fit the iPad)
• Waze (Live mapping application. Has some game elements.)
• Maps (folder of map applications)
• Notes
• Flipboard (Beautiful application for visualization of online content. Mostly Twitter, but also Flickr and Google Reader RSS posts)
• Twitter (folder of Twitter applications)
• Twitter (Official Twitter application)
• Books (folder of book and reading applications)
• Evernote (The everything notebook storage application)
• AccuWeather
• TuneIn Radio (paid 99 cents, worth $5)
• Google (search and access to Google applications)
• Google Voice (access and use your account on a mobile device)
• Instapaper (Read it later application. Used in conjunction with a browser bookmarklet tool)
• WordPress (application to create blog posts using WordPress)
• Wikihood (Wikipedia entries for places near you)